Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors，TNF-R1 and Fas. Several novel death receptor including DR3，DR4，and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor 6. Like TNF-R1，DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kB and JNK. DR6 is widely expressed in human tissues and cell lines.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects ~68 kDa of DR6 in samples from human， mouse and rat origins.
免疫原
Synthetic peptide surrounding amino acid 622 of rat DR6
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的DR6蛋白發生免疫反應.
保存建議
提供的DR6抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該DR6抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
