Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors，TNF-R1 and Fas. Several novel death receptors including DR3，DR4，DR5，and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domain. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex，which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
應用類型
Western blot analysis （1-2 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects an approximately 60 kDa human SODD by Western blot analysis. HeLa and THP-1 cell lysate can be used as positive control.
免疫原
Synthetic peptide mapping to the N-terminus of human SODD
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的SODD蛋白發生免疫反應.
保存建議
提供的SODD抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 1% BSA， 0.02%硫柳汞的PBS （pH 7.2）緩沖液中.請將該SODD抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
