Fodrin is a universally expressed membrane-associated cytoskeletal protein consisting of - and B-subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. -Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N-terminal 150 kDa，C-terminal 120 kDa，and 35 kDa major products. Cleavage of -Fodrin leads to membrane malfunction and cell shrinkage.
應用類型
Western blot analysis （0.5-4 ug/ml） and in in Immunohistochemistry （10-20 ug/ml）.
免疫原
Synthetic peptide surrounding amino acid 162 of mouse alpha-Fodrin
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的alpha-Fodrin蛋白發生免疫反應.
保存建議
提供的alpha-Fodrin抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該alpha-Fodrin抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
