MKK3 is a protein kinase that phosphorylates the p38 MAPK. Phosphorylation by MKK3 occurs on threonine and tyrosine residues and increases the activity of p38 to stimulate transcription factors ATF2 and Elk-1. MKK3，together with MKK6，serves as upstream regulators of p38 MAPK activation. A structural variant，MKK3b，has been identified that contains 29 more amino acids at its N-terminus.
應用類型
Western blot analysis （0.5-4 ug/ml） and immunoprecipitation. However， the optimal conditions should be determined individually.
免疫原
E. coli-expressed full-length human MKK3
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的MKK3蛋白發生免疫反應.
保存建議
提供的MKK3抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有50%甘油， 1% BSA， 0.02%硫柳汞的PBS （pH 7.2）緩沖液中.請將該MKK3抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
