PID/MTA2，also termed MTA1-L1，is a novel molecule that has been found to be involved in p53 pathway. PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylastion of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis. PID/MTA2 is ubiquitously expressed in human tissues.
應用類型
Western blotting （1 ug/ml）. An approximately 75 kDa band can be detected. HeLa cell lysate can be used as a positive control. No cross-reactivity to MTA1.
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 655 of human PID/MTA2
