COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID （Nonsteroidal anti-inflammatory drugs） such as aspirin. Prostaglandins （PGs） formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body，whereas PGs formed by COX-2 primarily mediate pain，fever，and inflammation. COX-1 is constitutively expressed，with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis.
應用類型
Western blotting （1-4 ug/ml）， immunoprecipitation， and Immunohistochemistry. However， the optimal concentrations should be determined individually. The antibody recognizes 70 kDa COX-1 of human， mouse and rat origins. It does not cross-react with COX-2.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 586 of mouse Cox-1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Cox-1蛋白發生免疫反應.
保存建議
提供的Cox-1抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02% 疊氮鈉的PBS緩沖液中.請將該Cox-1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
