COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID （Nonsteroidal anti-inflammatory drugs） such as aspirin. Prostaglandins （PGs） formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body，whereas PGs formed by COX-2 primarily mediate pain，fever，and inflammation. COX-1 is constitutively expressed，with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 66 kDa human Cox-2. It does not cross-react with Cox-1. Jurkat cell lysate （Cat.# 2401-100） can be used as a positive control.
免疫原
Synthetic peptide mapping to the C-terminus of human Cox-2
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的Cox-2蛋白發生免疫反應.
保存建議
提供的Cox-2抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該Cox-2抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
