Catenin is one of the key downstream effectors in the Wnt signaling pathway. It has been implicated to play an important role in early embryonic development and tumorigenesis. B-catenin can be destabilized by GSK-3B or other kinases by phosphorylating it at serines 33，37，45 and threonine 41. Mutations of these phosphorylation sites in B-catenin have been found in many tumor cell lines.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 90 kDa phosphorylated B-Catenin （Ser45） of human， mouse， and rat origin.
免疫原
Synthetic phospho-peptide corresponding to residues surrounding Ser45 of human B-Catenin
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Phospho-b-Catenin蛋白發生免疫反應.
保存建議
提供的Phospho-b-Catenin抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS緩沖液中.請將該Phospho-b-Catenin抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
