Heat shock proteins （HSPs） are ubiquitously expressed in all organisms. A major function of HSP90 and other HSPs is to act as molecular chaperones. HSP90 forms a complex with glucocorticoid receptor （GR）， rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP56 or cyclophilin-40， forming an aporeceptor complex. HSP90 also exists as a dimer with other proteins such as p60/sti1 and p23， forming an aporeceptor complex with estrogen and androgen receptors.
應用類型
Western blotting （0.5-4 ug/ml）， in immunoprecipitation （10-20 ug/ml） and Immunohistochemistry （frozen sections， 10-20 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes Hsp90α and Hsp90β of human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 714 of human Hsp90
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Hsp90蛋白發生免疫反應.
保存建議
提供的Hsp90抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該Hsp90抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
