Chemokines play an important role in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups，CXCR and CCR，based on the 2 major classes of chemokines. One of the CCR receptors，CCR1，is expressed on neutrophils，monocytes，lymphocytes，and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein （MIP-1 ），eotaxin，as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The anti-CCR1 antibody recognizes 42 kDa human and monkey CCR1 and in a lesser extent the mouse CCR1 in Western blot analysis.
免疫原
Synthetic peptide surrounding amino acid 341 of human CCR1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、猴種屬來源的CCR1蛋白發生免疫反應.
保存建議
提供的CCR1抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該CCR1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
