Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups，CXCR and CCR，based on the 2 major classes of chemokines. One of the CCR receptors，CCR1，is expressed on neutrophils，monocytes，lymphocytes，and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein （MIP-1 ），eotaxin，as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects ~42 kDa of CCR2 in samples from human， mouse and rat origins. Reactivity to other species has not been determined.
免疫原
Synthetic peptide surrounding to amino acid 353 of rat CCR2
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的CCR2蛋白 發生免疫反應.
保存建議
提供的CCR2抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該CCR2抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
