Chemokines play important roles in inflammation and critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups，CXCR and CCR，based on the 2 major classes of chemokines. One of the CCR receptors，CCR3 （eotaxin receptor），is expressed on eosinophils and certain T cell population respond to a variety of CC chemokines apart from eotaxin，including RANTES，monocyte chemotactic protein （MCP）-2，MCP-3，and MCP-4. CCR3 facilitated infection by a more restricted subset of primary viruses，and binding of the CCR3 ligand，eotaxin，and inhibited infection by these isolates.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide surrounding amino acid 332 of rat CCR3
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的CCR3蛋白發生免疫反應.
保存建議
提供的CCR3抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該CCR3抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
