NPM （Nucleophosmin） is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions，including assembly and transport of ribosomes，cytoplasmic/nuclear trafficking，regulation of DNA polymerase alpha activity，centrosome duplication and molecular chaperoning activities. The NPM gene is also known for its fusion with the anaplastic lymphoma kinase （ALK） receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain，which results in activation of the fused kinase.
應用類型
Western blotting （1-2 ug/ml） and Immunohistochemistry （10-20 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide corresponding to amino acids surrounding the N-terminus of human NPM
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的NPM蛋白發生免疫反應.
保存建議
提供的NPM抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS緩沖液中.請將該NPM抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
