DNA mismatch repair genes have been found to be associated with hereditary nonpolyposis colorectal cancer （HNPCC）. Inherited mutations in the MSH2 were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic，gastric，breast，ovarian and small cell lung cancers also display microsatellite instability suggests that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
應用類型
Western blotting （1-4 ug/ml）， immunoprecipitation （15-25 ug/ml）， and Immunohistochemistry （15-25 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes the MSH2 of human， mouse， and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide mapping to a region between 1-50 of MSH2
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的MSH2蛋白 發生免疫反應.
保存建議
提供的MSH2抗體 產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02% 疊氮鈉的PBS緩沖液中.請將該MSH2抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
