The TLR （toll-like receptors） family of proteins are characterized by a highly conserved Toll homology （TH） domain，which is essential for Toll-induced signal transduction. TLR1，as well as the other TLR family members，are type I transmembrane receptors that characteristically contain an extracellular domain consisting of several leucine-rich regions along with a single cytoplasmic Toll/IL-1R-like domain. TLR2 and TLR4 are activated in response to lipopolysacchride （LPS） stimulation，which results in the activation and translocation of NFκB and suggests that these receptors are involved in mediating inflammatory responses. Expression of TLR receptors is highest in peripheral blood leukocytes，macrophages，and monocytes. TLR6 is highly homologous to TLR1，sharing greater that 65% sequence identity，and，like other members of TLR family，it induces NFκB signaling upon activation.
應用類型
Western blotting （1:200-1000） and ELISA （1:100-500）. However， the optimal concentrations should be determined individually.
免疫原
Recombinant human TLR1
來源宿主
山羊
反應性
經檢測驗證，可與人種屬來源的TLR1蛋白發生免疫反應.
保存建議
提供的TLR1抗體產品為100 ul 無色溶液，其濃度為N/A，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS緩沖液中.請將該TLR1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
