Paxillin is one of the key components of integrin signaling. Tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization. Paxillin is phosphorylated by another focal adhesion component，focal adhesion kinase （FAK），at tyrosine 118. Phospho-Tyr118 may provide a docking site for recruitment of other signaling molecules to focal adhesions.
應用類型
Western blotting （1-2 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide corresponding to residues near the C-terminal sequence of human Paxillin
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Paxillin蛋白發生免疫反應.
保存建議
提供的Paxillin抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02% 疊氮鈉的PBS緩沖液中.請將該Paxillin抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
