PKGs are cyclic GMP-dependent protein kinases （also designed cGKs） that are classified into two types，PKGI and PKGII. Studies have shown that cGKs and cyclic AMP-dependent kinases （cAKs） are highly homologous protein kinase families with similar substrate specificities. Phosphorylation of cellular proteins by both families of kinases leads to alterations in calcium mobilization，protein phosphatase activity，ion channel function，gene transcription，smooth muscle contractility and platelet aggregation. However，recent studies using mice deficient in PKGs have shown that cGMP kinases regulate very specifically distinct pathways which are separate from those used by cyclic AMP kinases.
應用類型
The antibody can be used for Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes 75 and 85 kDa PKG， corresponding to the molecular mass of two PKG isoforms.
免疫原
Synthetic peptide near the N-terminus of human PKG
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠、雞、倉鼠、牛、兔種屬來源的PKG蛋白 發生免疫反應.
保存建議
提供的PKG抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該PKG抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
