Tau，a microtubule-binding protein which serves to stabilize microtubules in growing axons，is found to be hyperphosphorylated in paired helical filaments （PHF），the major fibrous component of neurofibrillary lesions associated with Alzheimer’s disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified，all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimer’s disease.
應用類型
Western blotting （1:1000）， immunoprecipitation （1:500）； and Immunohistochemistry （1:100）. However， the optimal concentrations should be determined individually. The antibody recognizes 45-60 kDa human Tau-13. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to the N-terminus of the longest isoform of human Tau
來源宿主
小鼠
反應性
經檢測驗證，可與人種屬來源的Tau-13蛋白發生免疫反應.
保存建議
提供的Tau-13抗體產品為100 ul 無色溶液，其濃度為N/A，溶解于包含有50%甘油， 1% BSA和0.02% 疊氮鈉的PBS緩沖液中.請將該Tau-13抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
