Inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were initially demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10-45% of pancreatic，gastric，breast，ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene，designated PMS1 and PMS2，have been identified and shown to be mutated in the germline of HNPCC patients.
應用類型
Western blotting （0.5-4 ug/ml）， immunoprecipitation （10-20 ug/ml） and Immunohistochemistry （10-20 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide surrounding amino acid 846 of human PMS2
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的PMS2蛋白 發生免疫反應.
保存建議
提供的PMS2抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該PMS2抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
