PTEN （phosphatase and tensin homologue deleted on chromosome ten） phosphatase is a tumor suppressor gene implicated in a wide variety of human cancers. PTEN encodes the 403 amino acid polypeptide originally described as a dual-specificity protein phosphatase. The main substrates of PTEN are inositol phospholipids generated by the activation of the phosphoinositide 3 kinase （PI3K）. PTEN is a major negative regulator of the PI3K/Akt signaling pathway.
應用類型
Western blotting （1-2 ug/ml） and immunoprecipitation （10-20 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Recombinant human full length PTEN
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的PTEN蛋白 發生免疫反應.
保存建議
提供的PTEN抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有50%甘油， 1% BSA和0.02%硫柳汞的PBS緩沖液中.請將該PTEN抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
