Adipose tissue is an energy reserve in animals. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism，such as adiponectin leptin. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor alpha （PPAR alpha）. PPAR alpha has recently been reported to target a novel gene encoding the secreted protein FIAF （fasting-induced adipose factor）. FIAF is expressed predominantly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies suggest that FIAF represents a novel endocrine signal helping to regulate metabolism，especially under fasting conditions.
應用類型
Western blotting （0.5-4 ug/ml）. It recognizes ~50 kDa FIAF from samples of mouse and rat origins.
免疫原
Synthetic peptide surrounding amino acid 84 of mouse FIAF
來源宿主
兔
反應性
經檢測驗證，可與小鼠、大鼠種屬來源的FIAF蛋白 發生免疫反應.
保存建議
提供的FIAF抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該FIAF抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
