The matrix metalloproteinases （MMP） are a family of peptidase enzymes responsible for the degradation of extracellular matrix components，including collagen，gelatin，fibronectin，laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester，lipopolysaccharide （LPS） or staphylococcal enterotoxin B （SEB）. MMP catalysis requires both calcium and zinc. Unlike other members of the MMP family，MMP-8 is expressed exclusively in inflammatory conditions. MMP-8 is also the predominant collagenase expressed in ulcers and healing wounds.
應用類型
Western blotting （1-4 ug/ml）. Other applications have not been tested. Blocking peptide （Cat.# 3528RBP-50） is available separately. The antibody recognizes latent （85 kDa） and active forms （25-65 kDa） of MMP8 from human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 448 of rat MMP-8
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的MMP-8蛋白 發生免疫反應.
保存建議
提供的MMP-8抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該MMP-8抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
