The matrix metalloproteinases （MMP） are a family of peptidase enzymes responsible for the degradation of extracellular matrix components，including collagen，gelatin，fibronectin，laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester，lipopolysaccharide （LPS） or staphylococcal enterotoxin B （SEB）. MMP catalysis requires both calcium and zinc. MMP-9 （also designated 92-kDa type IV collagenase or gelatinase B） has been shown to degrade bone collagens in concert with MMP-1 （also designated interstitial collagenase，fibroblast collagenase or collagenase-1），and cysteine proteases and may play a role in bone osteoclastic resorption.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes the full length （proenzyme， 92 kDa） and cleaved （active enzyme， 84 kDa） MMP-9 in samples from human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 110 of human MMP-9
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的MMP-9蛋白 發生免疫反應.
保存建議
提供的MMP-9抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該MMP-9抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
