The matrix metalloproteinases （MMP） are a family of peptidase enzymes responsible for the degradation of extracellular matrix components，including collagen，gelatin，fibronectin，laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester，lipopolysaccharide （LPS） or staphylococcal enterotoxin B （SEB）. MMP catalysis requires both calcium and zinc. MMP-11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Blocking peptide （3531RBP-50） is available separately. The antibody recognizes the latent form （~68 kDa） and the active forms （~55 kDa and ~40 kDa） of MMP-11 from human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 464 of mouse MMP-11
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的MMP-11蛋白 發生免疫反應.
保存建議
提供的MMP-11抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該MMP-11抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
