TRAFs （TNF receptor associated proteins） form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs （TRAF1-TRAF6）. TRAF3，originally named CRAF1，interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha （TNF-alpha） receptor-associated factors. TRAF3 binds only a single site，which contains the sequence PEQET，whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes 67 kDa TRAF3 of human， mouse and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues around amino acid 107 of human TWEAK Receptor
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的TRAF3蛋白 發生免疫反應.
保存建議
提供的TRAF3抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該TRAF3抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
