Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF，BLyS，TALL-1，THANK，and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors，TACI and BCMA，for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI，which bind to BAFF and April，BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases，and activate NF-kB and c-Jun N-terminal kinase.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide surrounding amino acid 159 of mouse BAFF-R
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的BAFF-R蛋白發生免疫反應.
保存建議
提供的BAFF-R抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該BAFF-R抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
