The IRAK family members play an important role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK-4 is a novel member in the IRAK family. Over expression of IRAK-4 activates NFkB and MAPK pathways. Animas and human lacking IRAK-4 are impaired in their responses to viral and bacterial challenges.
應用類型
Western blotting （2-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 50 kDa human IRAK-4. Reactivity of the antibody to other species has not been tested.
免疫原
Synthetic peptide mapping to the C-terminus of human IRAK-4
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的IRAK-4蛋白 發生免疫反應.
保存建議
提供的IRAK-4抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該IRAK-4抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
