Dystrophin is one of the actin-binding proteins that are involved in anchoring the cytoskeleton to the plasma membrane. Dystrophin expression is found in muscle brain tissues，where it is located to the inner surface of the plasma membrane. It is suggested that alternative splicing of the caboxy terminus allows dystrophin to interact with a variety of proteins. Loss of dystrophin-associated proteins in Duchenne afflicted muscle is due to the absence of dystrophin rather than to muscle degradation and lack of dystrophin results in the loss of linkage between the cytoskeleton and extracellular matrix.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects ~60 and 130 kDa of Dystrophin in samples from human， mouse and rat origins. Reactivity to other species has not been determined.
免疫原
Synthetic peptide surrounding amino acid 3656 of human Dystrophin
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Dystrophin蛋白 發生免疫反應.
保存建議
提供的Dystrophin抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該Dystrophin抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
