KiSS-1 has been reported to suppress metastases of melanomas and breast carcinomas without affecting tumorigenicity. Human KiSS-1 transcripts are predominately expressed in the brain and placenta. Expression of KiSS-1 reduces the level of NFkB p50/p65 binding to the MMP9 promoter and correlates with diminished expression of the 92 kDa type IV collagenase （MMP-9）. KiSS-1 may regulate events downstream of cell-matrix adhesion in mechanisms involving cytoskeletal reorganization.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody recognizes 16 kDa human KiSS-1 in Western blot analysis with Jurkat cell lysate. Blocking peptide （Cat.# 3590BP-50） is available separately.
免疫原
Synthetic peptide surrounding amino acid 17 of mouse KiSS-1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的KiSS-1蛋白發生免疫反應.
保存建議
提供的KiSS-1抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該KiSS-1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
