Apoptosis plays an important role in many cellular processes. Dio-1 （Death Inducer-O bliterator-1），a putative transcription factor，has been indicated to function in the onset of apoptosis. Dio-1 expression is upregulated when an apoptosis is detected. It translocates to the nucleus，and activates apoptosis during limb development. Dio-1 expression can be suppressed by caspase inhibitors and Bcl-2 expression.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Other applications have not been tested. The antibody recognizes the 62 kDa human and mouse Dio-1 in Western blot analysis. Jurkat cell lysate and mouse small intestine tissue lysate can be used as positive controls.
免疫原
Synthetic peptide near the N-terminus of mouse Dio-1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠種屬來源的Dio-1蛋白發生免疫反應.
保存建議
提供的Dio-1抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該Dio-1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
