The Voltage-Dependent Anion Channel （VDAC or mitochondrial Porin）I is an outer membrane mitochondrial protein. The VDAC protein is thought to form the major pores through which adenine nucleotides are transferred through the outer mitochondrial membrane. VDAC has also been implicated in the formation of the mitochondrial permeability transition pore complex in apoptotic cells. This complex，formed by VDAC，ANT，and CypD is thought to allow the mitochondria to undergo metabolic uncoupling and irreversible morphologic changes that ultimately destroy the mitochondria during apoptosis.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes ~31 kDa VDAC/Porin from samples of human， mouse， rat， bovine， pig， and rabbit origins.
免疫原
Synthetic peptide surrounding amino acid 189 of human VDAC
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠、牛、兔種屬來源的VDAC/Porin蛋白發生免疫反應.
保存建議
提供的VDAC/Porin抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該VDAC/Porin抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
