HDAC1 is an active component of transcriptional corepressor complexes which can be recruited to specific promoter regions via transcriptional factors. HDAC1 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions，which leads to the inhibition of gene transcription.
應用類型
Western blotting （0.5-4 ug/ml）， Immunoprecipitation （10-20 ug/ml）， and Immunohistochemistry （10-20 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects the 62 kDa histone deacetylase 1. It does not cross-react with other HDAC proteins including HDAC2， 3， 4， 5， 6， 7， and 8.
免疫原
Synthetic peptide corresponding to the C-terminus of human HDAC1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的HDAC1蛋白發生免疫反應.
保存建議
提供的HDAC1抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該HDAC1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
