Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression,schizophrenia,Parkinson’s disease and drug abuse (Kish et al.,2001; Zhu et al.,2000; Zhu et al.,1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al.,2000; Salvatore et al.,2001; Dunkley et al.,2004).
應用類型
The antibody can be used for Western blotting (1:1000). However, the optimal conditions should be determined individually.
免疫原
SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma.
來源宿主
兔
反應性
經檢測驗證,可與哺乳動物種屬來源的Tyrosine Hydroxylase蛋白發生免疫反應
保存建議
提供的100 ul Tyrosine Hydroxylase抗體產品為無色溶液其濃度為N/A溶解于包含有50%甘油, 0.01% BSA、150 mM NaCl和10 mM HEPES緩沖液(pH 7.5)中.請將該Tyrosine Hydroxylase抗體產品置于-20 °C冷凍保存,建議分裝使用以避免反復凍融.