PAX genes encode nuclear transcription factors that may function as major controllers of developmental processes in both vertebrates and invertebrates. Mutations in murine PAX genes underlie three natural mouse alleles and several corresponding human syndromes （aniridia，foveal hypoplasia and Peters’ anomaly）. Murine PAX genes have been shown to be proto-oncogenes. Furthermore，human PAX genes have recently been demonstrated to play an influential part in some common human cancers such as brain tumors and lymphomas. All PAX genes encode a DNA-binding domain termed the paired domain and in addition some also encode a second binding domain--the paired type homeobox. PAX6 is involved in the early development of the optical vesicle and has been shown to interact with Six3，another important visual development protein.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes ~32 kDa and 47 kDa isoforms of PAX6 in samples from human， mouse and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 303 of rat PAX6
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的PAX6蛋白發生免疫反應.
保存建議
提供的PAX6抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該PAX6抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
