Liver X receptors （LXRs） are oxysterol activated nuclear receptors which are involved in the regulation of genesis and metabolism of cholesterols and bile acids. LXRs form heterodimeric complexes with the retinoic acid receptors （RARs） once activated by their respective oxysterol ligands. Two known isoforms，alpha and beta，are differentially expressed； the alpha isoform predominantly expressed in liver，whereas beta isoform expression has been shown to be ubiquitous.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Other applications have not been determined. The antibody detects 49 kDa LXR alpha and beta subunits of human， mouse， rat and bovine LXR. Cross-reactivity to other species has not been determined. Jurkat cell lysate （Cat.# 2401-100） and mouse small intestine tissue lysate （Cat.# 2601-100） can be used as positive controls.
免疫原
Synthetic peptide surrounding amino acid 435 of human LXR
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的LXR蛋白發生免疫反應.
保存建議
提供的LXR抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該LXR抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
