Lectin-like oxidized low-density-lipoprotein receptor-1 （LOX-1），also known as oxidized low-density-lipoprotein receptor-1 （OLR-1），belongs to the C-type lectin family. LOX-1 binds and supports the internalization of multiple structurally unrelated macromolecules including oxidized LDL，advanced glycation end products （AGE），activated platelets，bacteria，apoptotic or aged cells，and heat shock proteins. Human LOX-1 gene encodes a 273 amino acid residues （aa） protein with a short N-terminal intracellular domain，a transmembrane domain，an extracellular stalk/neck region followed a C-type lectin-like domain （CTLD）. The expression of LOX-1 is induced by proinflammatory or proatherogenic stimuli，as well as by oxidized LDL itself and hemodynamic or oxidative stress. LOX-1-dependent oxidized LDL uptake also induces apoptosis by inducing the expression of the pro-apoptotic Bax and downregulation of the anti-apoptotic Bcl-2.
應用類型
Western blotting （0.5-4 ug/ml）， detecting the pro- （~50 kDa） and the mature （~30 kDa） forms of Lox-1 in samples from human， mouse and rat origins. Other applications have not been determined.
免疫原
Synthetic peptide near the N-terminus of human Lox-1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的LOX-1蛋白發生免疫反應.
保存建議
提供的LOX-1抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該LOX-1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
