FK506-binding protein 38 （FKBP38），a member of the immunophilin family，has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane （OMM）. Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion，resulted in the translocation of Bcl-2 and Bcl-xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Blocking peptide （Cat.# 3666BP-50） is available separately. The antibody recognizes a ~40 kDa band in samples from human， mouse and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 344 of mouse FKBP38
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的FKBP38蛋白發生免疫反應.
保存建議
提供的FKBP38抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有0.1% BSA， 20%甘油和0.02%硫柳汞的PBS緩沖液中.請將該FKBP38抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
