BIN-1 is a tumor suppressor protein that was identified in a genetic screen for proteins that interact with the MCY oncoprotein. BIN-1 inhibits the oncogenic activity of MYC，possibly through activating or facilitating apoptosis. BIN is a short-lived protein with a half-life of about 2 hours.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Other applications have not been tested. The antibody recognizes ~65 kDa band in samples from human， mouse and rat origins. A cleavage fragment （~45 kDa） can also be detected in apoptotic samples. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 578 of mouse BIN-1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Bin1蛋白發生免疫反應.
保存建議
提供的Bin1抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有0.1% BSA， 30%甘油和0.01%硫柳汞的PBS緩沖液中.請將該Bin1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
