COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID （Nonsteroidal anti-inflammatory drugs） such as aspirin. Prostaglandins （PGs） formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body，whereas PGs formed by COX-2 primarily mediate pain，fever，and inflammation. COX-1 is constitutively expressed，with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans，COX-3 encodes proteins with completely different amino acid sequences than COX-1 or COX-2 and without COX activity. It has been suggested COX-3 as the key to unlocking the mystery of the mechanism of action of acetaminophen.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide mapping to the N-terminus of mouse Cox-3
來源宿主
兔
反應性
經檢測驗證，可與小鼠種屬來源的Cox-3蛋白發生免疫反應.
保存建議
提供的Cox-3抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該Cox-3抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
