uPAR （Urokinase plasminogen activator receptor） is a 55 kDa glycoprotein I-anchored surface receptor specific for urokinase plasminogen activator （uPA）. Upon binding to uPAR，uPA converts the surface bound，large serum B-globulin，plasminogen to plasmin. Plasmin，which is also designated fibrinolysin，is a trypsin-like enzyme that acts on Arg-Lys bonds and induces pericellular proteolysis in fibrin and fibrinogen，and thereby contributes to the systematic activation of the coagulation cascade. uPA and uPAR are known to be overexpressed in mesenchymal and epithelial tumor cells and are required for tumor invasion and metastasis.
應用類型
Western blotting （0.5-1 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 33 kDa rat uPAR. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 51 of rat uPAR
來源宿主
兔
反應性
經檢測驗證，可與大鼠種屬來源的uPAR蛋白發生免疫反應.
保存建議
提供的uPAR抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該uPAR抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
