The matrix metalloproteinases （MMP） are a family of peptidase enzymes responsible for the degradation of extracellular matrix components，including collagen，gelatin，fibronectin，laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester，lipopolysaccharide （LPS） or staphylococcal enterotoxin B （SEB）. MMP catalysis requires both calcium and zinc. MMP-12 may contribute to elastin degradation occurring in granulomatous skin diseases and may also participate in macrophage migration through the epidermal and vascular basement membranes in inflammatory disorders.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. Mouse small intestine tissue lysate can be used as a positive control. The antibody recognizes the MMP-12 of human and mouse origins.
免疫原
Synthetic peptide surrounding amino acid 460 of human MMP-12
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠種屬來源的MMP-12蛋白發生免疫反應.
保存建議
提供的MMP-12抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油和0.02%硫柳汞的PBS緩沖液中.請將該MMP-12抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
