High molecular weight serine protease inhibitors （serpins） are large superfamily of proteins，which bind to and inactivate serine proteinases. In 1995 Sprecher et al. cloned 2 novel serpins，termed PI8 and PI9，from human placenta cDNA library. Sequencing showed that PI8 encodes 376-amino acids. PI8 are localized to the cytoplasm of transfected cells and was able to form an SDS- complex. PI8 is implicated to inhibit furin enzymatic activity and plays a role in platelet-regulated pathophysiological responses.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 40-45 kDa human PI-8. Reactivity to other species has not been tested.
免疫原
Synthetic peptide surrounding amino acid 10 of human PI-8
來源宿主
兔
反應性
經檢測驗證，可與人種屬來源的PI-8蛋白發生免疫反應.
保存建議
提供的PI-8抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有1% BSA， 30%甘油和0.02%硫柳汞的PBS緩沖液中.請將該PI-8抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
