LDL-related proteins，LRP-5 and LRP-6，are members of the LDL receptor superfamily，which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin，leading Axin degradation and B-catenin stabilization.
應用類型
Western blot analysis （1-2 ug/ml）. However， the optimal conditions should be determined individually. Detects full length and a proteolytic fragment of LRP-6.
免疫原
Synthetic peptide derived from human LRP-6
來源宿主
小鼠
反應性
經檢測驗證，可與人、小鼠種屬來源的LRP-5/6蛋白發生免疫反應.
保存建議
提供的LRP-5/6抗體產品為100 ug 無色溶液，其濃度為1.0 mg/ml，溶解于包含有0.15 M NaCl， 25%甘油， 0.5% BSA和0.01%疊氮鈉的10 mM Tris-glycine （pH 7.0）緩沖液中.請將該LRP-5/6抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
