Fibroblast growth factor receptor substrate 2 （FRS2） is a 70-90kDA member of the FSR family of lipid-anchored docking protein. FRS2 contains Grb2 binding sites，a myristylation sequence and a PTP domain. Activation of FGFR leads to tyrosine phosphorylation of FRS2 and the binding of phosphorylated FRS2 to GRB2/SOS complexes. Once phosphorylated，FRS2 recruits SH2 domain-containing proteins including Grb2 and SHP-2 mediating downstream signalling. FRS2 thus，acts as an intermediary between FGF and Trk receptors that links receptor tyrosine kinase to Ras/MAPK signaling pathway.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually.
免疫原
Synthetic peptide surrounding amino acid 493 of human FRS2
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的FRS2蛋白發生免疫反應.
保存建議
提供的FRS2抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該FRS2抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
