Low density lipoprotein receptors （LDLR） are cell surface glycoproteins that regulate LDL cholesterol by scavenging LDL from the blood. LDLR is characterized by a cluster of cysteine-rich class A repeats，EGF-like repeats，the O-linked sugars domain and six YWTD or class B repeats. Mutations in the LDLR gene cause autosomal dominant disease such as familial hypercholesterolemia （FH） and atherosclerosis.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes mature LDLR （160 kDa）， LDLR precursor （120 kDa） and LDLR monomer （~50 kDa）.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 850 of human LDLR
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠、牛、倉鼠種屬來源的LDLR蛋白發生免疫反應.
保存建議
提供的LDLR抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該LDLR抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
