Stearoyl-CoA desaturase （SCD） is a regulatory enzyme involved in the synthesis of oleate and palmitoleate. Oleate and palmitoleate are the main components of membrane phospholipid，triglycerides and cholesterol esters. SCD plays an important role in cellular cholesterol homeostasis and also in the secretion processes of triacylglycerol and phospholipid. Inhibition of SCD could be a useful treatment for metabollic disorders such as obesity and hepatic steatosis.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes ~61 kDa ECM-1 of human， mouse， and rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 546 of mouse ECM-1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的ECM蛋白發生免疫反應.
保存建議
提供的ECM抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該ECM抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
