Notch proteins are transmembrane receptor that regluate cell fate decisions. Four Notch homologs have been identified in mammals namely Notch 1，Notch 2，Notch 3 and Notch 4. The membrane ligand for Notch includes Jagged 1，Jagged 2 and Delta. Notch 1 is a 270 kDa transmembrane receptor that can be activated by Delta （Dl） ligand. Activation of Notch 1 will result in the proteolytic cleavage of Notch 1 into a 120 kDa length protein.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes a 120 kDa band from samples of human and mouse origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 1760 of mouse Notch1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Notch 1蛋白發生免疫反應.
保存建議
提供的Notch 1抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該Notch 1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
