Mitofusin 2 （Mfn 2） is mostly expressed in the heart and muscle tissues. It is a transmembrane protein that mediates mitochondria fusion and plays a central role in the maintenance of mitochondrial morphology. A GTPase domain is required for the function of Mitofusin proteins. Mutations in Mfn2 can lead to Charcot-Marie-Tooth disease，a common inherited disorder of the peripheral nervous system. Mfn2 may also be associated with obesity and/or apoptosis.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 68 kDa and 86 kDa bands from samples of human， mouse， rat origins. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 719 of human Mitofusin 2
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Mitofusin 2蛋白發生免疫反應.
保存建議
提供的Mitofusin 2抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該Mitofusin 2抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
