Transcription factor A mitochondria （TFAM） is an important activator of mitochondrial DNA transcription and replication. Studies in mice have shown that TFAM is required to regulate the mitochondrial genome copy number and is important for embryonic development. TFAM has been associated with mitochondrial disorder which includes ocular myopathy and muscular wasting in humans. Kearns-Sayre syndrome was shown in mouse model when expression of the gene was eliminated by targeted disruption in heart and muscle cells.
應用類型
Western blotting （0.5-4ug/ml）. However， the optimal concentrations should be determined individually. The antibody recognizes 27 kDa band from rat kidney tissue lysate. Reactivity to other species has not been tested.
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 225 of rat TFAM
來源宿主
兔
反應性
經檢測驗證，可與大鼠種屬來源的TFAM蛋白發生免疫反應.
保存建議
提供的TFAM抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該TFAM抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
