Sp transcription factor family has a highly conserved DNA-binding domain composed of zinc fingers. The Sp family is comprised of Sp1，Sp2，Sp3 and Sp4 that regulates transcription by binding to consensus GC- and GT-box regulatory elements in the target genes. Sp1，Sp3 and Sp4 have a high binding capacity for GC box while Sp2 binds weakly to the GT box. Sp3 has been shown to have to a bifunctional transcription factor that can either stimulates or represses the transcription of various genes.
應用類型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Other applications have not been tested. The antibody detects ~86-100 kDa Sp3 in samples from human， mouse and rat origins.
免疫原
Synthetic peptide surrounding amino acid 766 of mouse Sp3
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Sp3蛋白發生免疫反應.
保存建議
提供的Sp3抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該Sp3抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
